Birc5 proliferation

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August undefined, 2024

WebMay 11, 2024 · Through rescue experiments, we proved that BIRC5 reversed miR-3940-3p-mediated cell proliferation or apoptosis in BBOX1-AS1-dysregulated GC cells. BBOX1-AS1 accelerates GC proliferation by sponging miR-3940-3p to upregulate BIRC5 expression, which may guide a new direction into the therapeutic strategies of GC. Gastric cancer … WebMar 21, 2024 · In particular, the representative cell proliferation marker (MKI67), proliferative cell nuclear antigen (PCNA), 39 DNA topoisomerase II alpha (TOP2A), a baculoviral inhibitor of apoptosis repeat-containing protein 5 (BIRC5/Survivin), 14 master regulator of cell proliferation, forkhead box M1 (FOXM1), 40 E2F family, 41 and cyclin …

β-catenin driven cancers require a YAP1 transcriptional complex …

WebJul 8, 2024 · It includes five gene markers of proliferation – MKI67 (Ki67), STK15 (AURKA), BIRC5 (survivin), CCNB1 (cyclin B1), MYBL2 (MYB proto-oncogene like 2); PGR … WebAug 21, 2024 · Aberrant expression of BIRC5 in various malignancies has been confirmed closely associated with cell cycle, proliferation, migration, immune infiltration, and the … clean syntax in excel

Potential Involvement of BIRC5 in Maintaining …

WebSurvivin, also called baculoviral inhibitor of apoptosis repeat-containing 5 or BIRC5, is a protein that, in humans, is encoded by the BIRC5 gene. ... In adult organisms, apoptosis is needed to maintain differentiated tissue by striking the balance between proliferation and cell death. It is known that intracellular proteases called caspases ... WebDec 12, 2012 · Using BIRC5- or BCL2L1-specific shRNAs (Figure 4SA, B), we found that depletion of BIRC5 or BCL2L1 impaired the proliferation and AI growth of β-catenin-dependent cell lines (Figure 4A, B). These observations corroborate recent observations that cancer cell lines that harbor activating mutations in β-catenin are particularly sensitive to ... WebThe results indicate that KLF2 could suppress BIRC5 expression transcriptionally. CONCLUSION. In summary, the miR-92a-3p/KLF2/BIRC5 regulation axis was identified … cleansysteam gmbh \\u0026 co. kg

BIRC5 Modulates PD-L1 Expression and Immune …

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WebSep 6, 2024 · The expression of FEN1 in TCGA liver cancer tissues was positively correlated with that of MCM2 (r = 0.853, P = 0.000), BIRC5 (r = 0.809, P = 0.000), and RFC4 (r = 0.852, P = 0.000) (Figs. 6B – 6D), suggesting that FEN1 may play as important a role in the progression of liver cancer as do MCM2, BIRC5, and RFC4. The ONCOMINE … Apoptosis, the process of programmed cell death, involves complex signaling pathways and cascades of molecular events. This process is needed for proper development during embryonic and fetal growth where there is destruction and reconstruction of cellular structures. In adult organisms, apoptosis is needed to maintain differentiated tissue by striking the balance between proliferation and cell death. It is known that intracellular proteases called caspases degrade the … cleansy lolWebJan 10, 2024 · The BIRC5 gene encodes a survivin protein belonging to class III of inhibitors of apoptosis, IAP. This protein serves a dual role. This protein serves a dual role. First, it … clean symphony

"WebAs a mitotic spindle checkpoint gene, baculoviral IAP repeat containing 5 (BIRC5) serves pivotal roles in the development of various types of malignant tumors. In the present … " - Birc5 proliferation

Birc5 proliferation

BIRC5 is a prognostic biomarker associated with tumor immune …

WebWe found robust expression of Mki67 and other markers of proliferation (Anln, Aurka, Birc5, Pcna, and Plk1) used by Soonpaa et al. in neonatal cardiomyocytes (Fig. 3G), in agreement with our bulk mRNA-sequencing data (Fig. 1F). However, expression of these proliferation markers was largely negligible in adult cardiomyocytes (Fig. 1F). WebJun 1, 2024 · Overall, we define distinct pathways downstream of oncogenic ARID1A mutation, with nonessential WNT-inhibited mucinous differentiation in parallel with essential transcriptional FOXM1/BIRC5-stimulated proliferation, illustrating the general utility of organoid-based forward genetic cancer analysis in human cells.

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WebJan 7, 2024 · BIRC5, on the contrary, is commonly considered an anti-apoptotic molecule, promoting cell division and tumor progression and it is widely regarded as potential therapeutic target. ... Importantly, cell proliferation upon genetic disruption is dramatically reduced, as demonstrated by a 90% reduction in radioactive-thymidine incorporation . … WebDec 8, 2024 · miR-92a-3p promotes breast cancer proliferation by regulating the KLF2/BIRC5 axis. Title: miR-92a-3p promotes breast cancer proliferation by regulating the KLF2/BIRC5 axis. Inhibition of USP1 enhances anticancer drugs-induced cancer cell death through downregulation of survivin and miR-216a-5p-mediated upregulation of DR5.

WebIntroduction: Human Baculoviral inhibitor of apoptosis repeat-containing 5 (BIRC5) which encodes survivin exhibits multiple biological activities, such as cell proliferation and apoptosis. WebThe results indicate that KLF2 could suppress BIRC5 expression transcriptionally. CONCLUSION. In summary, the miR-92a-3p/KLF2/BIRC5 regulation axis was identified in breast cancer proliferation, which may serve as emerging cancer biomarkers and provide promising strategies for breast cancer therapy. AUTHOR CONTRIBUTIONS

WebMar 21, 2024 · Multitasking protein that has dual roles in promoting cell proliferation and preventing apoptosis (PubMed:9859993, 21364656, ... (CPC) composed of at least BIRC5/survivin, CDCA8/borealin, INCENP, AURKB or AURKC; in the complex forms a triple-helix bundle-based subcomplex with INCENP and CDCA8 (PubMed:17956729). … WebJan 7, 2024 · BIRC3 (cellular IAP2) and BIRC5 (survivin) are two of the eight members of the human IAPs family. This family is characterized by the presence of the baculoviral …

WebApr 22, 2011 · Genetic regulation of mammalian heart size is poorly understood. Hippo signaling represents an organ-size control pathway in Drosophila, where it also inhibits cell proliferation and promotes apoptosis in imaginal discs.To determine whether Hippo signaling controls mammalian heart size, we inactivated Hippo pathway components in …

WebJul 24, 2024 · Genes in component 2 were mainly related to cell proliferation (e.g., Birc5, Mki67, and Top2a). Cell cycle regression analysis and GSVA scoring revealed a correlation between proliferative ability ... clean syringe exchangeWebNuclear factor kappa B (NF-κB) activation has been proposed as a cardinal feature of tumourigenesis, although the precise mechanism, frequency, relevance, and extent of NF-κB activation in lymphomas ... clean synthetic wigWebJun 19, 2012 · Over-expression of BIRC5 could significantly attenuate the effect of miR-203 on the inhibition of MDA-MB-231 cell proliferation. (A) BIRC5 protein expression was … clean synthetic urineWebJan 11, 2024 · BIRC5 is an immune-related gene that inhibits apoptosis and promotes cell proliferation. It is highly expressed in most tumors and leads to poor prognosis in … clean syringes programsWebMay 27, 2024 · Further, effect of hnRNPA2B1 on BIRC5 alternative splicing was investigated. We show that overexpression of hnRNPA2B1 in GC is correlated with poor … clean synthetic leatherWebBIRC5 INFORMATION. Proteini. Full gene name according to HGNC. Baculoviral IAP repeat containing 5. Gene namei. Official gene symbol, which is typically a short form of the gene name, according to HGNC. BIRC5 (API4, EPR-1, survivin) Protein classi. Assigned HPA protein class (es) for the encoded protein (s). clean syrup off carpetWebMar 25, 2024 · The BIRC5 (Baculoviral IAP Repeat Containing 5) gene located on chromosome 17 (17q25.3) encodes for the Survivin protein, which is a member of the … clean syrup