Brefeldin a solubility
WebBrefeldin A (BFA) is a natural fungal metabolite which has been used extensively to study intracellular transport by vesicles or endosomes. Early studies demonstrated that BFA … WebBrefeldin A (BFA) is a fungal macrocyclic lactone and a potent, reversible inhibitor of intracellular vesicle formation and protein trafficking between the endoplasmic reticulum (ER) and the Golgi apparatus. Email: [email protected] Nature 610.7931 (2024): 366-372 (2024): 1-17 21.1 (2024): 1-17 Molecular Cancer 21.1 (2024): 1-18 39 (2024): 1-16
Brefeldin a solubility
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WebBrefeldin A (BFA) is a fungal metabolite which disrupts the structure and function of the Golgi apparatus by inhibiting transport of proteins from ER to Golgi and inducing retrograde protein transport from the Golgi apparatus to the endoplasmic reticulum. [ 1] BFA inhibits the transport of sphingomyelin to the surface of mammalian cells. [ 2] WebAug 1, 2024 · Brefeldin A 1 (BFA) is a bicyclic lactone produced by fungi of the genus Penicillium.In 1958, V. I. Singleton*, N. Bohonos, and A. J. Ullstrup at Purdue University …
Brefeldin A is a lactone antiviral produced by the fungus Penicillium brefeldianum. Brefeldin A inhibits protein transport from the endoplasmic reticulum to the golgi complex indirectly by preventing association of COP-I coat to the Golgi membrane. Brefeldin A was initially isolated with hopes to become an antiviral … See more The compound gets its name from a species of anamorph fungus of the Penicillium genus known as Eupenicillium brefeldianum, though it is found in a variety of species that span several genera. It was first … See more In mammalian and yeast cells, the main target of brefeldin A appears to be a guanine nucleotide exchange factor (GEF) called GBF1. GBF1 is a member of the Arf family of GEFs … See more • Unfolded protein response • Endoplasmic reticulum stress response (ER stress) See more Brefeldin A is found naturally as a white to off-white crystalline solid. It forms a clear colorless solution when dissolved. It is soluble in methanol (10 mg/mL), ethanol (5 mg/mL), DMSO (20 mg/mL), acetone, and ethyl acetate (1 mg/mL) without the aid of heating. It is poorly … See more The toxological effects of brefeldin A have not been studied extensively yet. Some animal LD50 values have been reported including 250 … See more • Klausner RD, Donaldson JG, Lippincott-Schwartz J (March 1992). "Brefeldin A: insights into the control of membrane traffic and organelle structure". J. Cell Biol. 116 (5): 1071–80. doi:10.1083/jcb.116.5.1071. PMC 2289364. PMID See more WebSolubility Data for Brefeldin A. Solvent Max Conc. mg/mL Max Conc. mM; Solubility; DMSO: 14.02: 50: Preparing Stock Solutions for Brefeldin A. The following data is …
WebThe drug brefeldin A (BFA) has pr of ound effects on organelle structure and function in all eukaryotic cells examined including Saccharomyces cerevisiae. 23 Many trafficking … WebBrefeldin A is also an autophagy and mitophagy inhibitor[3]. Brefeldin A is a CRISPR/Cas9 activator[5]. Brefeldin A inhibits HSV-1 and has anti-cancer activity[5]. IC₅₀ & Target CRISPR/Cas9 HSV-1 In Vitro Brefeldin A (BFA) treatment for 15 h or 40 h, causes dramatic swelling of the Endoplasmic Reticulum (ER) and shifts its
WebBrefeldin A (BFA) is a natural fungal metabolite which has been used extensively to study intracellular transport by vesicles or endosomes. Early studies demonstrated that BFA reversibly interferes with protein trafficking and secretion mediated by the Golgi apparatus and endoplasmic reticulum. 1,2,3 BFA directly and reversibly inhibits Sec7 domain …
WebHotline: 4008203792Inhibitors Agonists Screening Librarieswww.MedChemExpress.cnBrefeldin ACat. No. HY16592CAS No. 203501,文库 … swivel chairs harvey normanWebab84340 staining golgin-97 in MCF7 cells treated with brefeldin A (ab120299), by ICC/IF. Increase in Golgin-97 expression correlates with increased concentration of brefeldin A, as described in literature. The cells were incubated at 37°C for 1.5 h in media containing different concentrations of ab120299 (brefeldin A) in DMSO, fixed with 4% … swivel chairs high backWebBrefeldin A (BFA) is a lactone antibiotic and a specific inhibitor of protein trafficking. Brefeldin A blocks the transport of secreted and membrane proteins from endoplasmic reticulum to Golgi apparatus. Brefeldin A is … swivel chair simple machineWebBrefeldin A is a fungal metabolite and blocks the forward transport between the endoplasmic reticulum and Golgi apparatus, Brefeldin … swivel chair shooting benchWebsolubility. DMSO: 10 mg/mL (Store stock solutions at -20 °C) ... Brefeldin A (BFA) is a fungal metabolite which disrupts the structure and function of the Golgi apparatus. BFA is an activator of the sphingomyelin cycle. Brefeldin A-mediated apoptosis has been observed in human tumor cells. swivel chairs home goodsWebBrefeldin is an antibiotic produced by Penicillum brefeldianum S-464, Pen. cyaneum S-ll, Pen. decumbens, Pen. simplicissimum S-543, etc. Brefeldin A has anti-candida, aspergillus and anti-tumor activity. Ordering Information Add to cart Specification Reference Reading Recommended Products International : 1-631-504-6093 swivel chairs in austinWeb开馆时间：周一至周日7:00-22:30 周五 7:00-12:00; 我的图书馆 swivel chairs in stock