C. tuerk and l. gold science 1990 249 505–510
Web指数扩增富集配体的系统进化技术(systematic evolution of ligands by exponential enrichment,SELEX)是20世纪90年代初新出现的一种化学组合筛选技术,由Tuerk C和Gold L在1990年首次提出[1],从而开启了一个研究蛋白质与核酸相互作用的崭新时代[2-3]。 WebAug 1, 1995 · High affinity RNA ligands to human nerve growth factor (NGF) were selected from pools of random RNA using SELEX [Tuerk, C. and Gold, L. (1990) Science, 249, 505-510]. Nerve growth factor, which is a protein required for the development of neurons, is not known to bind nucleic acids as part of its natural function.
C. tuerk and l. gold science 1990 249 505–510
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WebSep 24, 2024 · Artificial evolution was used to identify a light-producing deoxyribozyme called Supernova. This catalyzes a chemiluminescent reaction in the presence of the 1,2 …
WebAug 1, 1995 · High affinity RNA ligands to human nerve growth factor (NGF) were selected from pools of random RNA using SELEX [Tuerk, C. and Gold, L. (1990) Science, 249, … WebHigh affinity RNA ligands to human nerve growth factor (NGF) were selected from pools of random RNA using SELEX [Tuerk, C. and Gold, L. (1990) Science, 249, 505-510].
WebTo select aptamers with modified nucleotides, the appropriate DNA polymerase must be designated.We studied eight polymerases and demonstrated that incorporating a tryptophan-like nucleotide into aptamer libraries by emulsion PCR and KOD XL had an insignificant effect on the PCR bias and did not distort the sequence space, thus making … WebJan 5, 2015 · CB[7] SAM was prepared by simply dipping a gold surface into a solution of CB[7] (1.0 mM in deionized H 2 O) for 6 h as per the literature reports 15a and conveniently kept at RT until it was ready to be used as a sensor chip. Direct injections of CB[7] solution (1.0 mM in deionized H 2 O, 20 min, 20 µL min −1) onto a gold surface mounted in a …
WebAug 25, 1995 · Abstract. High affinity RNA ligands to human nerve growth factor (NGF) were selected from pools of random RNA using SELEX [Tuerk, C. and Gold, L. (1990) …
Web1 day ago · C. Tuerk, L. Gold Systematic evolution of ligands by exponential enrichment: RNA ligands to bacteriophage T4 DNA polymerase Science , 249 ( 1990 ) , pp. 505 - 510 , 10.1126/science.2200121 bip heathrowWebTuerk, C. and Gold, L. (1990) Systematic Evolution of Ligands by Exponential Enrichment: RNA Ligands to Bacteriophage T4 DNA Polymerase. Science, 249, 505 … bip heap inspectionWebEuropean Inventors of the Year 2006 in the category "Non-European countries" Larry Gold and Craig Tuerk (NeXstar Pharmaceuticals, Boulder, USA) with their SELEX technology … biphentin 30WebJun 8, 2006 · C Tuerk and L Gold, “Systemic evolution of ligands by exponential enrichment: RNA ligands to bacteriophage T4 DNA polymerase,” Science, vol. 249, no. 4968, pp. 505–510, 1990. View at: Google Scholar. D M Dykxhoorn and J Lieberman, ... P Aza-Blanc, C L Cooper, K Wagner, S Batalov, Q L Deveraux, ... biphenphosWebApr 9, 2024 · Compared with commonly used antibodies, aptamer, a class of functional oligonucleotides engineered by artificial combinatorial methodologies, exhibits better chemical and thermal stability, lower synthetic cost, and high affinity for all molecules theoretically (Tuerk and Gold, 1990; X. Wang et al., 2024; WilsonSzostak, 1999). biphentin 40-60WebC. Tuerk L. Gold (1990) Science 249 505–510 Occurrence Handle 1:CAS:528:DyaK3cXlt1OltLY%3D Occurrence Handle 2200121 CAS PubMed Google Scholar biphen n arenesWebApr 6, 2004 · Patent number: 7368236. Abstract: The present invention includes methods for the identification and production of improved nucleic acid ligands based on the SELEX … bi pheasant\\u0027s-eyes