Crbn knockout mice
WebCereblon (CRBN), a DCAFs (DDB1 and CUL4-associated factors), is a well-established protein associated with human mental retardation. Being a substra … Susceptibility of pentylenetetrazole-induced seizures in mice with Cereblon gene knockout BMB Rep. 2024 Sep;53(9):484-489.doi: 10.5483/BMBRep.2024.53.9.119. Authors Seung-Je Jeon 1
Crbn knockout mice
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WebThis product is a mouse antibody that recognizes human CRBN. It can be used in the following applications: WB, IHC, ELISA. Conjugation: NONE PE APC Biotin FITC HRP … WebApr 4, 2024 · Crbn knock-our (KO) mice, a loss-of-function animal model for Crbn, have normal brain development, but exhibit impaired cognitive function similar to CRBN -mutated human intellectual disability patients ( Higgins et al., 2004; Dijkhuizen et al., 2006; Papuc et al., 2015; Sheereen et al., 2024 ).
WebMar 14, 2024 · In this study, we demonstrate that adult male Crbn knock-out ( CrbnKO) mice exhibit deficits in hippocampal-dependent learning and memory tasks that are … WebOct 4, 2024 · To examine whether physiologic expression of Crbn I391V is sufficient to confer lenalidomide sensitivity to Csnk1a1 +/− hematopoietic cells, we bred Crbn I391V mice to Csnk1a1 conditional knockout mice in which Cre recombinase is under the control of the Mx1 promoter. 27 After inducing excision of the floxed Csnk1a1 allele in …
WebVoltage-gated ClC-2 channels are essential for chloride homeostasis. Complete knockout of mouse ClC-2 leads to testicular degeneration and neuronal myelin vacuolation. Gain-of-function and loss-of-function mutations in the ClC-2-encoding human CLCN2 gene are linked to the genetic diseases aldosteronism and leukodystrophy, respectively. The … WebFeb 7, 2024 · CRBN knockdown mitigates lipopolysaccharide-induced acute lung injury by suppression of oxidative stress and endoplasmic reticulum (ER) stress associated NF …
WebAug 22, 2014 · Whereas deficiency of Crbn repressed protein translation via activation of the AMPK-mTOR cascade in Crbn-knock-out mice, ectopic expression of the wild-type CRBN increased protein synthesis by inhibiting endogenous AMPK.
WebOct 1, 2024 · Since forebrain-specific conditional CRBN knockout mice splayed learning disabilities (Rajadhyaksha et al., 2012 ), CRBN was suggested to be related to brain (hippocampus) function, but the molecular mechanism and association with CRL4 CRBN E3 activity was unknown. memphis tn to evansville inWebJan 25, 2024 · Crbn KO mice exhibit a higher mortality rate following etoposide challenge Our results showed that CRBN affects the … memphis tn to haleyville alWebTo investigate the role of CRBN in modulating elastase-induced emphysema, we used Crbn knockout (KO) mice. Elastase-induced emphysematous changes were significantly aggravated in Crbn KO mice. Neutrophil infiltration, lung cell injury, and protein leakage into the bronchoalveolar space were more severe in Crbn KO mice than in wild-type (WT) … memphis tn to helena arWebKnockout validated Reacts with: Mouse, Human Isotype: IgG1 You may also be interested in Secondary Goat Anti-Mouse IgG H&L (Alexa Fluor® 488) (ab150113) Protein … memphis tn to eubank kyWebCRBN-KO mice showed high AMPK activity in various tissues and high resistance to a wide range of diseases, such as high fat diet-induced obesity, alcohol-induced fatty liver, ischemic heart... memphis tn to gulf shores alabamaWebIn this study, we demonstrate that adult male Crbn knock-out (Crbn KO) mice exhibit deficits in hippocampal-dependent learning and memory tasks that are recapitulated by focal knock-out of Crbn in the adult dorsal hippocampus, with no changes in … memphis tn to honolulu hawaiiWebJan 15, 2012 · We also inactivated crbn in forebrain neurons in conditional knock-out mice in which crbn exons 3 and 4 are deleted by cre recombinase under the direction of the Ca(2+)/calmodulin-dependent protein kinase II alpha promoter (CamKII(cre/+), crbn(-/-)). crbn mRNA levels were negligible in the HPC, CTX, and cerebellum (CRBM) of the … memphis tn to galveston tx