Paloma-2 trial
WebApr 1, 2024 · The PALOMA-2 study provides the largest body of evidence for patient-reported health-related quality of life (QOL) for patients with metastatic breast cancer … WebMay 20, 2016 · In PALOMA-1, an open-label Ph 2 trial, addition of P to L improved median PFS vs L alone (20.2 months [mo] vs 10.2 mo) in pts with first-line ER+/HER2– ABC with …
Paloma-2 trial
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WebOct 28, 2024 · A Study of Amivantamab Subcutaneous (SC) Administration for the Treatment of Advanced Solid Malignancies (PALOMA) The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. WebAbstract Background: PALOMA-2 confirmed that first-line palbociclib + letrozole improved progression-free survival (hazard ratio, 0.58; 95% confidence interval, 0.46-0.72) in postmenopausal women with estrogen receptor-positive (ER+)/human epidermal growth factor receptor 2-negative (HER2-) advanced breast cancer (ABC).
WebApr 19, 2016 · PALOMA-2 is a randomized (2:1), multicenter, multinational, double-blind Phase 3 study designed to assess PFS in postmenopausal women with ER+, HER2- … WebOct 20, 2024 · quently, the randomized, phase 3 trial PALOMA-2 confirmed that palbociclib substantially pro-longed progression-free survival, in combination with letrozole, as first-line therapy for estrogen-
WebJun 4, 2024 · The PALOMA-2 trial showed that in addition to substantially delaying progressive disease, IBRANCE as first-line treatment, in combination with letrozole, … PALOMA-2 was designed by an academic steering committee that included representatives from Pfizer, the industry sponsor (see the Supplementary Appendix, available with the full text of this article at NEJM.org). Pfizer supplied the investigators with the treatments used in the study. Data were … See more Hormone-receptorpositive breast cancer represents the largest therapeutic subtype of the disease, accounting for 60 to 65% of all malignant neoplasms of the breast. For more than 50 years, … See more The cyclin-dependent kinases (CDKs) are a large family of serinethreonine kinases that play an important role in regulating cell-cycle progression. The interaction of cyclin D with CDK4 … See more Women with ER-positive, HER2-negative advanced breast cancer were eligible for enrollment if they had not received prior systemic therapy for advanced disease. ER status was … See more In this double-blind, phase 3 study, patients were randomly assigned, in a 2:1 ratio, to receive 125 mg of palbociclib per day, administered … See more
WebOther trials also investigating CDK4/6 inhibitors as first-line therapy in postmenopausal patients (PALOMA-2 and MONARCH 3) have yet to report final overall survival.
WebJun 8, 2024 · PALOMA-2 is a randomized, double-blind, phase 3 trial in first-line ER+/HER2– ABC that confirmed a clinically and statistically significant improvement in … screenplays that offer coverageWebPurpose: In the initial PALOMA-2 ( NCT01740427) analysis with median follow-up of 23 months, palbociclib plus letrozole significantly prolonged progression-free survival (PFS) … screenplay step outline examplesWebJun 10, 2024 · The phase III PALOMA-2 study, conducted by Richard S. Finn, MD, of the David Geffen School of Medicine at the University of California, Los Angeles, and … screenplay storyboardWebOct 20, 2024 · quently, the randomized, phase 3 trial PALOMA-2 confirmed that palbociclib substantially pro-longed progression-free survival, in combination with letrozole, as first … screenplay storyboard templatescreenplays to studyWebPurpose: In PALOMA-2, palbociclib plus letrozole significantly improved progression-free survival (PFS) as initial treatment of estrogen receptor-positive/human epidermal growth factor receptor 2-negative advanced breast cancer. We assessed the benefit of palbociclib plus letrozole in Asians. screenplay story beatsWebIn the phase 2, open-label, PALOMA-1 trial, palbociclib plus letrozole significantly prolonged progression-free survival (PFS) versus letrozole alone (hazard ratio, 0.488; 95% CI 0.319‒0.748; P = 0.0004; median PFS, 20.2 vs 10.2 months, respectively) in postmenopausal women with estrogen receptor-positive (ER+)/HER2- ABC. screenplay story structure