Smad3 breast cancer
Webb24 mars 2014 · We show that Smad3 interacts with Ahnak through MH2 domain and that Ahnak stimulates Smad3 localization into nucleus leading to potentiating TGFβ-induced transcriptional activity of R-Smad.... WebbHere, we report, for the first time, that mutation of the Smad3 linker phosphorylation sites markedly inhibited primary tumor growth, but significantly increased lung metastasis of breast cancer cell lines. In contrast, mutation of the Smad3 C-tail phosphorylation sites had the opposite effect.
Smad3 breast cancer
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WebbRNA interference of CCR2 expression in breast cancer cells significantly inhibited CCL2-induced migration, survival, and phosphorylation of Smad3 and p42/44MAPK proteins. Disruption of Smad3 expression in mammary carcinoma cells blocked CCL2-induced cell survival and migration and partially reduced p42/44MAPK phosphorylation. Webb6 apr. 2024 · Breast cancer (BC) is the most prevalent malignant tumor, surpassing lung cancer as the most frequent malignancy in women. Drug resistance, metastasis, and immune escape are the major factors affecting patient survival and represent a huge challenge in BC treatment in clinic. The cell- and subcellular organelle-targeting …
WebbHere, SMAD3 is identified as a nonhistone substrate of lysine acetyltransferase 6A (KAT6A). The acetylation of SMAD3 at K20 and K117 by KAT6A promotes SMAD3 … WebbFurthermore, knockdown of SMAD3 produced a consistent phenotype of miR-135-5p overexpression in breast cancer cells. Mechanistically, SMAD3, a pivotal transcriptional modulator of TGF-β/SMAD pathway, for the first time, was analyzed and identified as a target gene of miR-135-5p by bioinformatic algorithms and dual-luciferase reporter assays.
Webb14 okt. 2024 · Additionally, recent work in HER2+ SKBR3 breast cancer cells identified an association between TGFβ and HER2/AKT signaling through phosphorylation of SMAD3 at the S208 linker region site, leading to loss of tumor suppression and increased invasiveness of these cells. 47 Similar associations among noncanonical SMAD3 … Webb19 okt. 2012 · Disruption of Smad3 expression in mammary carcinoma cells blocked CCL2-induced cell survival and migration and partially reduced p42/44MAPK phosphorylation. …
Webb20 okt. 2024 · Aberrant SMAD3 activation has been implicated as a driving event in cancer metastasis, yet the underlying mechanisms are still elusive. Here, SMAD3 is identified as a nonhistone substrate of...
Webb15 jan. 2013 · The prevalence of SMAD4, SMAD2, and SMAD3 mutations in sporadic CRCs was 8.6% (64 of 744), 3.4% (25 of 744), and 4.3% (32 of 744), respectively. A significant … tsv cleanerWebb14 dec. 2009 · Our results show that, depending on the type of R-Smad silenced the metastatic potential of the human breast cancer cells is differentially and significantly affected. Specific silencing of... pho 16th streetWebb8 dec. 2024 · Identification of Smad2 and Smad3 specific binding sites in a breast cancer cell line model: Organism: Homo sapiens: ... We identify Smad2 and Smad3 specific binding site in a breast cancer breast cell model MDA-MB-231 using LAP-tag GFP fusion proteins under the control of endogenous regulatory elements. tsv cleaningWebb1 dec. 2016 · Bcl-3 was required for the expression of downstream TGF β signaling genes that are involved in breast cancer lung metastasis. Bcl-3 knockdown enhanced the … tsv clubhaus oftersheim speisekarteWebb4 mars 2010 · We stably knocked down Smad2 or Smad3 expression in MDA-MB-231 breast cancer cells. The TGF-beta-induced Smad3-mediated transcriptional response … pho 16 wpbWebb5 juli 2024 · Smad3 TGFβ triple negative breast cancer Introduction Triple negative breast cancer (TNBC) is an aggressive breast cancer subtype. Characterized by the absence of hormone receptor and Her2 receptor expression, it is unresponsive to anti-hormonal and Her2-targeted therapies. pho 16th vietnamese grillWebbEffective inhibition of breast cancer stem cell properties by quercetin-loaded solid lipid nanoparticles via reduction of Smad2/Smad3 phosphorylation and β-catenin signaling … pho 16th street mall